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Green Organic Dutchman and Caliper Foods report positive study results from water-soluble CBD technology

Higher cannabinoid absorption was observed for Caliper CBD within 15 minutes compared to the maximum absorption of CBD in oil in 45 minutes

Green Organic Dutchman and Caliper Foods report positive study results from water-soluble CBD technology
TGOD said it will commercialize organic CBD dissolvables in Canada in December through “fast-acting formulations” leveraging the technology with its lineup of organic teas, shots, chewables, and ready-to-drink beverages

The Green Organic Dutchman Holdings Ltd (TSE:TGOD) (OTCMKTS:TGODF) and Caliper Foods unveiled positive results Monday from a preliminary human pharmacokinetic study of Caliper CBD, a proprietary water-soluble powder that can be added to food and beverages.

In a statement, TGOD said it will commercialize organic CBD dissolvables in Canada in December through “fast-acting formulations” leveraging the technology with its lineup of organic teas, shots, chewables, and ready-to-drink beverages.

Similarly, in the US, Caliper Foods plans to release Caliper CBD, its own line of precision-dosed CBD dissolvables in the Fall.

READ: High-flying cannabis firm The Green Organic Dutchman applies for Nasdaq listing

"We are delighted with the pharmacokinetic study results as they confirm the enhanced bioavailability and consistent absorption rates of our proprietary ingredient technology, which can infuse both CBD and THC,” said Keith Woelfel, director of R&D at Caliper Foods in a statement.

“This study confirms that consumers absorb 4.5 times more CBD with Caliper CBD than with CBD in MCT oil,” he added.

Medium chain triglyceride, or MCT oil is most commonly extracted from coconut oil, as more than 50% of the fat in coconut oil comes from MCTs.

Working on next phase of clinical study

"Our R&D team is working closely with TGOD on the next phase of the clinical study, which, if it confirms the pharmacokinetic results in additional product forms, will make Caliper Foods' and TGOD's product suites highly differentiated in terms of substantiated quality," said Woelfel.

For the study, half the participants were administered 30 mg of Caliper Foods' water-soluble CBD powder in 8 ounces of water, while the other half received 30 mg of CBD dispersed in MCT oil. Blood samples were drawn at pre-determined times over six hours.

Early data shows that the group that received Caliper CBD demonstrated faster onset within 15 minutes, with higher concentrations achieved at 15 minutes compared to the maximum concentration achieved at 45 minutes with the CBD in oil formulation, and a 4.5-fold higher observed total bioavailability. The CBD was largely eliminated from the body after about 6 hours for both Caliper CBD and CBD oil subjects, and a more rapid reduction was observed with the Caliper CBD subjects after 45 minutes.

As a follow-up, the companies will now conduct a confirmatory clinical Phase 1A PK study to test the Caliper CBD technology in TGOD's planned portfolio of products including beverages, teas, infusers, and capsules. The study will be conducted with a top US academic institution.

Provides consistency and precision dosing

Dr Rav Kumar, the Chief Science Officer at TGOD, said the Canadian medical cannabis company was thrilled with the “consistency and precision” of Caliper Foods' technology available in Colorado, which TGOD will commercialize in Canada.

“Based on this early data, Caliper CBD provides a higher and faster absorption level when compared with CBD-infused oil, which opens a number of possibilities for both the medical and adult-use markets,” said Dr Kumar.

“Patients and consumers are increasingly informed, and we plan to seize on the market demand for organic CBD and THC-infused products backed by data-driven science and clinical evidence. We are enthusiastically awaiting our clinical Phase 1A PK results in time for Cannabis 2.0 in Canada," he added.

Caliper Foods' technology consists of a suite of zero-calorie, fast-acting, water-soluble solutions that can simply and easily infuse cannabinoids into food and beverages. TGOD has an exclusive deal with Caliper Foods to license Caliper CBD’s ingredient technology within Canada, and certain international jurisdictions outside the US.

The Green Organic Dutchman is building over 1.6 million square feet of cultivation and processing facilities across Ontario, Quebec, Jamaica and Denmark, and has a planned capacity of 219,000 kilograms.

It has organic hemp CBD oil operations in Canada, and through its wholly-owned subsidiary, HemPoland distributes premium hemp CBD oil in the European Union.

Contact Uttara Choudhury at [email protected]

Follow her on Twitter: @UttaraProactive 

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Price: 0.78 CAD

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