leadf
logo-loader
viewHumanigen, Inc.

Humanigen sees first coronavirus patient treated in Phase 3 trial of lenzilumab

The company believes the drug can potentially prevent serious outcomes in hospitalized patients with coronavirus (COVID-19) pneumonia

Person wearing scrubs and gloves with microscope
Lenzilumab is designed to mitigate what's known as the cytokine storm, an overactive immune response to the coronavirus that can cause inflammation and in the lungs and fluid build-up

Humanigen Inc (OTCQB:HGEN) announced Wednesday that the first coronavirus (COVID-19) patient has been dosed in a Phase 3 trial of its drug lenzilumab.

Lenzilumab is a proprietary anti-human granulocyte macrophage-colony stimulating factor (GM-CSF), which the company believes can potentially prevent serious outcomes in hospitalized patients with COVID-19 pneumonia.

Shares in New York gained 8.3% to $0.91 on the day.

The now ongoing trial is the first randomized, double-blind, placebo-controlled, multi-center, Phase 3 study of an anti-GM-CSF conducted in the US, the company said.

READ: Humanigen wins FDA nod to commence Phase III study of lenzilumab in coronavirus patients

"We are working with some of the top centers and clinicians in the US, alongside our contract research organization partner, CTI, to advance lenzilumab through Phase III with the intent to prevent serious and potentially fatal outcomes in high-risk patients who are hospitalized with COVID-19,” Humaigen CEO Cameron Durrant said in a statement.

“We are encouraged by our experiences in the compassionate use patients treated with lenzilumab and look forward to working with stakeholders to share these data."

Lenzilumab is designed to mitigate what's known as the cytokine storm, an overactive immune response to the coronavirus that can cause inflammation and in the lungs and fluid build-up, which can lead to respiratory issues and be contaminated by secondary bacterial pneumonia.

"GM-CSF has been shown to be earlier in the cascade, or ‘upstream', of multiple other cytokines, such as IL-6, IL-1 and TNF-α in cytokine storm,” Durrant added. “Excess GM-CSF production is thought to be the key initial trigger in certain disease states that may lead to significant ‘downstream' consequences, as these and other cytokines become elevated. 

“Therefore, the possibility exists that cytokine storm may be prevented or minimized by neutralizing GM-CSF. As the only company working on prevention of cytokine storm through GM-CSF neutralization for nearly three years, we have multiple accepted publications in this field, substantial safety data, including in patients with severe respiratory disease, and have filed extensive IP."

CTI Clinical Trial and Consulting Services is a global, full-service contract research organization (CRO), delivering a complete spectrum of clinical trial and consulting services. It has clinical trial experience across six continents and partners with research sites, patients, and sponsors to fulfil unmet medical needs.

----Updates for share price---

Contact Andrew Kessel at andrew.kessel@proactiveinvestors.com 

Follow him on Twitter @andrew_kessel

Quick facts: Humanigen, Inc.

Price: - -

OTCMKTS:HGEN
Market: OTCQB
Market Cap: -
Follow

Add related topics to MyProactive

Create your account: sign up and get ahead on news and events

NO INVESTMENT ADVICE

The Company is a publisher. You understand and agree that no content published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is...

In exchange for publishing services rendered by the Company on behalf of Humanigen, Inc. named herein, including the promotion by the Company of Humanigen, Inc. in any Content on the Site, the Company receives from...

FOR OUR FULL DISCLAIMER CLICK HERE

Humanigen announces 71.8 million dollars in financing

Humanigen (OTCQB: HGEN) Chairman and CEO Cameron Durant joined Steve Darling from Proactive Vancouver with news the company has secured almost 72 million dollars in financing. Durant discusses those making up that financing which is a big part of the story..

on 3/6/20

2 min read